Weghorn Lab

Evolutionary Processes Modeling

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Publications

Identification of cancer driver genes based on nucleotide context. Nature Genetics, 1-11. (2020) vbioRxiv
Dietlein*, F., Weghorn*, D., Taylor-Weiner, A., Richters, A., Reardon, B., Liu, D., Lander, E. S., Van Allen, E. M. and Sunyaev, S. R.

Germline de novo mutation rates on exons versus introns in humans. bioRxiv, 886879. (2019)
Rodriguez-Galindo, M., Sònia Casillas, Weghorn, D. and Barbadilla, A.

Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans. Molecular Biology and Evolution, 36.8, 1701. (2019) vbioRxiv
Weghorn*, D., Balick*, D. J., Cassa, C., Kosmicki, J., Daly, M. J., Beier, D. R. and Sunyaev, S. R.

Reply to 'Selective effects of heterozygous protein-truncating variants'. Nature Genetics, 51(1), 3. (2019)
Cassa*, C. A., Weghorn*, D., Balick*, D. J., Jordan*, D. M., Nusinow, D., Samocha, K. E., O'Donnell-Luria, A., MacArthur, D. G., Daly, M. J., Beier, D. R. and Sunyaev, S. R.

Bayesian inference of negative and positive selection in human cancers. Nature Genetics, 49(12), 1785. (2017) vSharedIt
Weghorn, D. and Sunyaev, S.

Identifying DNase I hypersensitive sites as driver distal regulatory elements in breast cancer. Nature Communications, 8(1), 436. (2017)
D'Antonio*, M., Weghorn*, D., D'Antonio-Chronowska, A., Coulet, F., Olson, K. M., DeBoever, C., Drees, F., Arias, A., Alakus, H., Richardson, A. L., Schwab, R. B., Farley, E. K., Sunyaev, S. R. and Frazer, K. A.

Estimating the selective effects of heterozygous protein-truncating variants from human exome data. Nature Genetics, 49(5), 806. (2017) vPMC
Cassa*, C. A., Weghorn*, D., Balick*, D. J., Jordan*, D. M., Nusinow, D., Samocha, K. E., O'Donnell-Luria, A., MacArthur, D. G., Daly, M. J., Beier, D. R. and Sunyaev, S. R. (2017).

Fitness landscape for nucleosome positioning. Proceedings of the National Academy of Sciences, 110(27), 10988-10993. (2013)
Weghorn, D. and Lässig, M.

*equal author contributions; co-corresponding authors